Key result
Efficient autoproteolytic processing of the MHV-A59 3C-like proteinase from its flanking hydrophobic domains requires the presence of microsomal membranes.
Membrane association is required for efficient autoproteolytic processing of the MHV-A59 3C-like proteinase from its flanking hydrophobic domains.
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Findings remain preclinical; leaves open membrane targeting of 3CLpro in human coronaviruses.
Hofbauer et al. (1997) studied Murine coronavirus MHV-A59 infection (in vitro). Microsomal membranes vs. Absence of microsomal membranes was evaluated on Autoproteolytic processing of the 3C-like proteinase (3CLpro). Efficient autoproteolytic processing of the MHV-A59 3C-like proteinase from its flanking hydrophobic domains requires the presence of microsomal membranes.
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