Key result
Tension generation in skinned rabbit psoas fibers occurs in the absence of chemical change as an entropy-driven transition between strongly bound crossbridges in the actomyosin-ADP state.
Population
Skinned rabbit psoas fibers
Design
Preclinical
Authors
Loading...
Refines crossbridge models in skeletal muscle; leaves open relevance to human cardiac contractility.
This study proposes a new mechanism for muscle contraction where tension generation is an entropy-driven transition indirectly coupled to phosphate release.
Davis et al. (1995) studied this question. Laser temperature jump and phosphate addition was evaluated on Kinetics and mechanism of tension generation. Tension generation in skinned rabbit psoas fibers occurs in the absence of chemical change as an entropy-driven transition between strongly bound crossbridges in the actomyosin-ADP state.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: