Key result
The CRT-REALITY trial is a planned randomized controlled study designed to evaluate whether CRT-D provides a clinical benefit over CRT-P in patients with non-ischemic heart failure without mid-wall fibrosis.
Why the study?
Does CRT-D reduce re-hospitalization for heart failure, ventricular tachycardia, and MACE compared to CRT-P in patients with non-ischemic heart failure, LVEF ≤35%, and no significant mid-wall fibrosis on CMR?
Population
Non-ischemic patients with reduced LVEF and optimal pharmacotherapy without significant mid-wall myocardial fibrosis on CMR
Comparison
CRT-D vs CRT-P
Design
Multicenter prospective randomized controlled trial
Authors
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CRT-D benefit over CRT-P remains untested in this population; the planned RCT will deliver the first direct evidence.
RCT (n=600)
Double-blind
1:1
Yes
Does CRT-D reduce re-hospitalization for heart failure, ventricular tachycardia, and MACE compared to CRT-P in patients with non-ischemic heart failure, LVEF ≤35%, and no significant mid-wall fibrosis on CMR?
The CRT-REALITY study is a randomized controlled trial designed to evaluate whether CRT-D provides additional benefit over CRT-P in patients with non-ischemic heart failure and no significant mid-wall fibrosis on CMR.
Táborský et al. (2021) conducted an RCT in Non-ischemic dilated cardiomyopathy and heart failure (n=600). Cardiac Resynchronization and Defibrillator Therapy (CRT-D) vs. Cardiac Resynchronization Therapy Pacemaker (CRT-P) was evaluated on Re-hospitalization for heart failure, ventricular tachycardia, major adverse cardiac events (MACE). The CRT-REALITY trial is a planned randomized controlled study designed to evaluate whether CRT-D provides a clinical benefit over CRT-P in patients with non-ischemic heart failure without mid-wall fibrosis.
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