Key result
The FMDV 3'-NCR and poly(A) sequences independently stimulate IRES-dependent translation, reaching over 6-fold enhancement in living cells under conditions of translation shut-off.
Population
Susceptible cells and in vitro translation systems using foot-and-mouth disease virus (FMDV) RNA constructs
Comparison
Presence of FMDV 3'-NCR and/or poly sequences in… vs RNA constructs lacking the 3'-NCR and/or poly…
Design
Preclinical
Authors
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May guide FMDV antiviral design; extends molecular data but leaves open in vivo relevance.
Effect estimate: >6-fold stimulation
The 3'-NCR and poly(A) sequences of FMDV independently stimulate IRES-driven translation, highlighting individual signals in the viral 3' end that ensure translation efficiency.
Sonia López de Quinto (2002) studied Foot-and-mouth disease virus (FMDV) translation. FMDV 3'-NCR and poly(A) sequences vs. RNA lacking 3' sequences was evaluated on IRES-dependent translation efficiency (>6-fold stimulation). The FMDV 3'-NCR and poly(A) sequences independently stimulate IRES-dependent translation, reaching over 6-fold enhancement in living cells under conditions of translation shut-off.
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