Key result
Cytoplasmic microinjection of FMDV RNA resulted in productive infections with an infectivity close to 1 p.f.u. per molecule, whereas nuclear injection was not infectious.
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Suggests cytoplasmic FMDV replication site; leaves open nuclear barriers in natural infection.
Belsham et al. (1988) studied Foot-and-mouth disease virus (FMDV) infection. Microinjection of FMDV RNA vs. Nuclear vs cytoplasmic injection was evaluated on Infectivity (productive infections). Cytoplasmic microinjection of FMDV RNA resulted in productive infections with an infectivity close to 1 p.f.u. per molecule, whereas nuclear injection was not infectious.
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