Exercise training significantly reversed the attenuated ANP-induced vasorelaxation and suppressed the abnormally enhanced PDE5 activity in the mesenteric arteries of spontaneously hypertensive rats.
Does exercise training improve ANP-induced vasorelaxation in mesenteric arteries of spontaneously hypertensive rats?
Exercise training alleviates ANP resistance in mesenteric arteries of spontaneously hypertensive rats by suppressing PDE5 activity, suggesting a novel mechanism for the antihypertensive effects of exercise.
p-value: p=<0.05
Proximal resistance vessels, such as the mesenteric arteries, contribute substantially to the peripheral resistance. The reactivity of resistance vessels to vasoactive substance like natriuretic peptides plays an important role in the regulation of blood pressure. In current study, we investigated the reactivity of mesenteric arteries to atrial natriuretic peptide (ANP), a well known vasodilating factor, in spontaneously hypertensive rats (SHR), as well as the effects of exercise training on it. As a result, ANP-induced vasorelaxation was attenuated in SHR with significantly increased phosphodiesterase type 5 (PDE5), and decreased cGMP/ANP ratio, compared with WKY rats as control. Intriguingly, the decreased reactivity to ANP in SHR was markedly reversed by exercise training. In addition, ANP resistance of in vitro mesenteric arteries was diminished by sildenafil a potent selective inhibitor of PDE5. In conclusion, ANP resistance occurs in resistance vessels of SHR, suggesting predisposition to hypertension, which can be reversed by exercise.
Yu et al. (Fri,) conducted a other in Hypertension (n=60). Exercise training vs. No exercise was evaluated on ANP-induced vasorelaxation of mesenteric arteries (p=<0.05). Exercise training significantly reversed the attenuated ANP-induced vasorelaxation and suppressed the abnormally enhanced PDE5 activity in the mesenteric arteries of spontaneously hypertensive rats.