Why the study?
Does 8 weeks of aerobic training improve skeletal muscle vasodilator formation in patients with essential hypertension?
Population
21 patients, including 10 diagnosed with essential hypertension and 11 normotensive controls
Comparison
8 weeks of aerobic training vs Pre-training baseline and normotensive control…
Design
Cohort
Follow-up
8 weeks
Key result
Aerobic training for 8 weeks normalized the impaired formation of interstitial adenosine and prostacyclin at the skeletal muscle microcirculatory level in patients with essential hypertension.
Authors
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May support microvascular benefits of aerobic training in hypertension; hypothesis-generating and requires RCT confirmation before practice change.
Does 8 weeks of aerobic training improve skeletal muscle vasodilator formation in patients with essential hypertension?
p-value: p=<0.05
Aerobic training normalizes the impaired capacity to form vasodilators (adenosine and PGI2) in the skeletal muscle microcirculation of patients with essential hypertension.
Hellsten et al. (2012) studied Essential hypertension (n=21). Aerobic training vs. Pre-training baseline and normotensive controls was evaluated on Leg vascular conductance, interstitial adenosine, and prostacyclin (PGI2) concentrations (p=<0.05). Aerobic training for 8 weeks normalized the impaired formation of interstitial adenosine and prostacyclin at the skeletal muscle microcirculatory level in patients with essential hypertension.
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