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September 7, 2011HypertensionOpen Access

After 16 weeks of training, resting muscle dialysate thromboxane A2 and prostacyclin concentrations were lower (P<0.05), and exercise-induced prostacyclin increased by 82% (P<0.05) in hypertensive subjects.

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Why the study?

Does physical training alter the balance of vasoactive compounds in skeletal muscle of individuals with essential hypertension?

Population

Individuals with essential hypertension (n=10) and normotensive control subjects (n=12)

Comparison

16 weeks of physical training vs Pre-training baseline and normotensive controls

Design

Cohort

Follow-up

16 weeks

Authors

AHAne H. HansenMNMichael NybergJBJens Bangsbo

Discussion

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Overview

Training-associated vasoactive shifts in hypertensive muscle are hypothesis-generating; should not change practice without RCTs.

Structured PICO

Does physical training alter the balance of vasoactive compounds in skeletal muscle of individuals with essential hypertension?

P
Population
Individuals with essential hypertension (n=10) and normotensive control subjects (n=12)
I
Intervention
16 weeks of physical training
C
Comparator
Pre-training baseline (for hypertensive subjects) and normotensive controls (for baseline protein levels)
O
Outcome
Levels of vasodilating and vasoconstricting compounds (thromboxane A2, prostacyclin, nucleotides, nitrite/nitrate) and related proteins in skeletal musclesurrogate

16 weeks of physical training improves the balance of vasoactive compounds in skeletal muscle of hypertensive individuals by reducing vasoconstrictors and enhancing exercise-induced vasodilators.

Cite This Study

Hansen et al. (2011) studied this question.

synapsesocial.com/papers/6a7032c2a528af2d65c3625chttps://doi.org/10.1161/hypertensionaha.111.176529
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