Why the study?
How does resistive loading of inspiration versus expiration affect ventilation and respiratory drive during mild hypercapnia in humans?
Population
16 human subjects (11 in main study, 5 additional for PDi/EMGDi)
Comparison
Resistive loading of inspiration or expiration… vs Unloaded phase / comparison between RI and RE
Design
Other
Authors
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Expiratory resistive loading suppresses ventilation more than inspiratory during hypercapnia; hypothesis-generating for respiratory mechanics, with no immediate clinical implications.
How does resistive loading of inspiration versus expiration affect ventilation and respiratory drive during mild hypercapnia in humans?
Ventilation is reduced more by expiratory resistive loading than by inspiratory loading due to greater respiratory phase time, without augmenting inspiratory drive.
Barnett et al. (1988) studied this question.
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