Why the study?
Does dl-sotalol consistently prolong the QT interval across different facilities in conscious dogs and monkeys using a standard telemetry protocol?
Population
36 male beagle dogs across 8 facilities and 28 male monkeys across 5 facilities.
Comparison
dl-Sotalol vs Vehicle (0.5 w/v% methylcellulose solution)
Design
Preclinical
Follow-up
24 hours post-dosing
Authors
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Confirms dl-sotalol as reliable QT positive control in multi-facility dog telemetry; leaves open standardization in monkeys and human translation.
Does dl-sotalol consistently prolong the QT interval across different facilities in conscious dogs and monkeys using a standard telemetry protocol?
A standard telemetry protocol using dl-sotalol reliably detects QT prolongation in conscious dogs across multiple facilities, supporting its robust use in preclinical safety pharmacology.
Sasaki et al. (2005) studied this question.
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