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November 1, 1991Pacing and Clinical Electrophysiology

Nonphysiological Left Heart AV Intervals as a Result of DDD and AAI “Physiological” Pacing

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Key result

Left heart AV intervals differed significantly from right heart AV intervals during right atrial pacing and right ventricular sensing or pacing (-130 to +300 msec; P<0.001).

Why the study?

Does conventional right heart AAI and DDD pacing cause nonphysiological left heart AV intervals in patients with pacemakers?

Population

16 patients with pacemakers (10 with DDD and 6 with AAI pacemakers)

Comparison

Conventional right heart AAI and DDD pacing vs Programmed right heart AV intervals (RAV)

Design

Cross-sectional

Authors

RCRaúl ChirifeTufts UniversityDODaniel F. OrtegaInstituto de Neurología CognitivaASArturo SalazarPeaceHealth St. John Medical Center

Discussion

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Implication

May produce nonphysiological LAV intervals with standard pacing; hypothesis-generating for conduction-adjusted programming effects on LV function.

Study Design

Type

Observational (n=16)

Structured PICO

Does conventional right heart AAI and DDD pacing cause nonphysiological left heart AV intervals in patients with pacemakers?

P
Population
16 patients with DDD and AAI pacemakers evaluated for left heart AV intervals during pacing.
E
Exposure
Conventional right heart AAI and DDD pacing
C
Comparator
Programmed right heart AV intervals (RAV)
O
Outcome
Actual left heart AV intervals (LAV)surrogate

Main Result

p-value: p=<0.001

Conventional right heart pacing in DDD and AAI modes can result in nonphysiological left heart AV intervals due to interatrial and interventricular conduction delays, suggesting these delays should be accounted for during pacemaker programming.

Cite This Study

Chirife et al. (1991) conducted an observational in Patients with DDD and AAI pacemakers (n=16). Right heart AAI and DDD pacing vs. Programmed right heart AV intervals (RAV) was evaluated on Difference between left heart AV intervals (LAV) and right heart AV intervals (RAV) (p=<0.001). Left heart AV intervals differed significantly from right heart AV intervals during right atrial pacing and right ventricular sensing or pacing (-130 to +300 msec; P<0.001).

synapsesocial.com/papers/6a22914ab65eef78bdffa31ahttps://doi.org/10.1111/j.1540-8159.1991.tb02760.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Radionuclide Evaluation of Dual Chamber Pacing: Comparison Between Variable AV Intervals and Ventricular Pacing1985 · 32 citations
  2. 2Hemodynamic Consequences of Atrioventricular and Ventriculoatrial Pacing1978 · 138 citations
  3. 3Optimum AV Interval in Dual Chamber Pacemakers1986 · 51 citations
  4. 4Hemodynamic and Symptomatic Consequences of Ventricular Pacing*1982 · 78 citations
  5. 5Hemodynamics of AV Synchrony and Rate1989 · 13 citations