Key result
Decreasing coronary artery size was not associated with increased eNOS protein content; rather, the smallest coronary arterioles had less eNOS protein per gram of total protein than large arteries.
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Challenges expected eNOS enrichment in coronary resistance vessels; leaves open vessel-size dependent NO bioavailability in human coronary disease.
Laughlin et al. (2003) studied this question. Decreasing coronary artery diameter vs. Large coronary arteries was evaluated on eNOS protein content (eNOS protein/g total artery protein). Decreasing coronary artery size was not associated with increased eNOS protein content; rather, the smallest coronary arterioles had less eNOS protein per gram of total protein than large arteries.
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