Key result
Exercise training increased eNOS protein content by 60-80% in small and large arterioles, resistance arteries, and small arteries, but not in conduit arteries.
Why the study?
Does exercise training increase eNOS protein expression in the coronary arterial tree in miniature swine?
Population
Miniature swine
Comparison
Exercise training for 16-20 weeks vs Remained sedentary for 16-20 weeks
Design
Preclinical
Follow-up
16-20 weeks
Authors
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Supports microvascular NO adaptations to exercise; leaves open human translation and conduit artery effects.
Does exercise training increase eNOS protein expression in the coronary arterial tree in miniature swine?
Exercise training induces nonuniform increases in eNOS protein expression along the coronary arterial tree in miniature swine, with greater increases in smaller arteries and arterioles.
Laughlin et al. (2001) studied this question. Exercise training vs. Sedentary was evaluated on eNOS protein content in the coronary arterial tree. Exercise training increased eNOS protein content by 60-80% in small and large arterioles, resistance arteries, and small arteries, but not in conduit arteries.
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