January 1, 2003Journal of Applied Physiology

Short-term training enhances endothelium-dependent dilation of coronary arteries, not arterioles

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Why the study?

Does short-term exercise training improve endothelium-dependent dilation in coronary arteries and arterioles in a swine model?

Population

Female Yucatan miniature swine (n=54)

Comparison

Short-term exercise training vs Sedentary controls

Design

Preclinical

Follow-up

7 days

Authors

MLM. Harold LaughlinUniversity of North Texas LRLeona J. RubinUniversity of California San Diego Medical Center JRJames W. E. RushPurchase College

Discussion

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Implication

Suggests segment-specific endothelial adaptations to exercise in swine; leaves open translation to human coronary disease.

Structured PICO

Does short-term exercise training improve endothelium-dependent dilation in coronary arteries and arterioles in a swine model?

Population

Female Yucatan miniature swine (n=54)

Intervention

Short-term exercise training (running on a treadmill for 1 h, at 3.5 mph, twice daily for 7 days)

Comparator

Sedentary controls

Outcome

Endothelium-dependent dilation (EDD) of coronary arteries and arterioles assessed by responses to bradykininsurrogate

Short-term exercise training enhances endothelium-dependent dilation in coronary conduit arteries but not arterioles in a swine model, independent of changes in eNOS or SOD-1 expression.

Cite This Study

Laughlin et al. (2003) studied this question.

synapsesocial.com/papers/6a744a10c2eb6969bf093149 https://doi.org/10.1152/japplphysiol.00246.2002

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Short-term training enhances endothelium-dependent dilation of coronary arteries, not arterioles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Short-term training enhances endothelium-dependent dilation of coronary arteries, not arterioles

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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