Key result
Type 1 diabetic patients had significantly reduced post-ischemic percent increase in skin endothelial- (p<0.0005) and sympathetic-dependent (p<0.0001) vasomotion compared to healthy controls.
Why the study?
Does type 1 diabetes impair skin vasomotion compared to healthy controls?
Population
90 subjects: 40 type 1 diabetic patients (T1D-pts) and 50 healthy controls
Comparison
3 minutes of forearm ischemia vs Healthy controls
Design
Case-control
Authors
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Type 1 diabetes was associated with reduced skin vasomotion; hypothesis-generating for autonomic and glycemic links, needs prospective validation.
Case-Control (n=90)
Does type 1 diabetes impair skin vasomotion compared to healthy controls?
p-value: p=<0.0005
Type 1 diabetes is associated with reduced stimulated skin endothelial- and sympathetic-dependent vasomotion, which correlates with autonomic function and glycemic control.
Rossi et al. (2013) conducted a case-control in Type 1 diabetes (n=90). Type 1 diabetes vs. Healthy controls was evaluated on Post-ischemic per cent increase in power spectral density of skin endothelial- and sympathetic-dependent vasomotion (p=<0.0005). Type 1 diabetic patients had significantly reduced post-ischemic percent increase in skin endothelial- (p<0.0005) and sympathetic-dependent (p<0.0001) vasomotion compared to healthy controls.
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