Key result
A 30-minute ischaemia-reperfusion injury in mice led to 13% LV infarct size and prominent calcification, compared to 52% infarct size and thinning after permanent LAD occlusion.
Authors
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Brief IR yields calcified, recoverable remodeling unlike permanent occlusion; extends murine MI models beyond thinning-focused paradigms.
Absolute Event Rate: 13% vs 52%
Celle et al. (2004) studied Cardiac ischaemia-reperfusion injury. 30 min ischaemic period followed by reperfusion vs. Permanent occlusion of the left anterior descending coronary artery (LAD) was evaluated on Infarct size (% of left ventricle). A 30-minute ischaemia-reperfusion injury in mice led to 13% LV infarct size and prominent calcification, compared to 52% infarct size and thinning after permanent LAD occlusion.
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