June 13, 2016Basic Research in CardiologyOpen Access

Regulator of G protein signalling 14 attenuates cardiac remodelling through the MEK–ERK1/2 signalling pathway

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Why the study?

Does RGS14 attenuate pathological cardiac remodeling in response to pressure overload?

Population

Human failing hearts, murine hypertrophic hearts, isolated hypertrophic cardiomyocytes, RGS14 knockout mice…

Comparison

Genetic manipulation of RGS14, constitutive… vs Wild-type mice or control conditions

Design

Preclinical

Authors

YLYing LiZhejiang Chinese Medical University XTXiaohong TangCentral South University XLXiaohui LiCentral South University

Discussion

Member takes

Implication

May protect against pressure-overload remodeling in mice; leaves open whether RGS14 targeting benefits human HF.

Structured PICO

Does RGS14 attenuate pathological cardiac remodeling in response to pressure overload?

Population

Human failing hearts, murine hypertrophic hearts, isolated hypertrophic cardiomyocytes, RGS14 knockout mice, and RGS14 transgenic mice subjected to aortic banding-induced pressure overload

Intervention

Genetic manipulation of RGS14 (knockout or transgenic overexpression), constitutive activation of MEK1, and inhibition of MEK-ERK1/2 by U0126

Comparator

Wild-type mice or control conditions

Outcome

Cardiac hypertrophy and fibrosis (cardiac remodeling)surrogate

RGS14 attenuates pathological cardiac remodeling through the MEK-ERK1/2 signaling pathway, highlighting its potential as a therapeutic target for heart failure.

Cite This Study

Li et al. (2016) studied this question.

synapsesocial.com/papers/6a22be1ddeb3a3e77c0e0a2f https://doi.org/10.1007/s00395-016-0566-1

Topics

HFrEF treatment Heart failure

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Regulator of G protein signalling 14 attenuates cardiac remodelling through the MEK–ERK1/2 signalling pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Regulator of G protein signalling 14 attenuates cardiac remodelling through the MEK–ERK1/2 signalling pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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