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October 1, 1975Journal of Biological ChemistryOpen Access

Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle.

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Key result

Cyclic AMP-dependent protein kinases from rabbit skeletal and bovine heart muscle share similar subunit structures but differ significantly in their regulatory subunits and cyclic AMP binding affinities.

Authors

FHFranz HofmannJBJA BeavoPBPJ Bechtel

Discussion

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Overview

Tissue-specific PKA differences warrant caution extrapolating skeletal data to heart; leaves open isoform-targeted cardiac therapies.

PICO

E
Exposure / Comparator
Rabbit skeletal muscle cyclic AMP-dependent protein kinase vs Bovine heart muscle cyclic AMP-dependent protein kinase
O
Primary Outcome
Biochemical properties including sedimentation constants, mobility, phosphorylation, and dissociation constants

Cite This Study

Hofmann et al. (1975) studied this question. Rabbit skeletal muscle cyclic AMP-dependent protein kinase vs. Bovine heart muscle cyclic AMP-dependent protein kinase was evaluated on Biochemical properties including sedimentation constants, mobility, phosphorylation, and dissociation constants. Cyclic AMP-dependent protein kinases from rabbit skeletal and bovine heart muscle share similar subunit structures but differ significantly in their regulatory subunits and cyclic AMP binding affinities.

synapsesocial.com/papers/6a22c9fb29c8bdba62cd75b1https://doi.org/10.1016/s0021-9258(19)40885-5
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