Key result
The ADRB2 Arg16Gly polymorphism was associated with higher body mass index and waist circumference exclusively in males, with no significant associations found for ADRB3 and GNB3 variants.
Why the study?
Do variants in ADRB2, ADRB3, and GNB3 genes affect body mass index and waist circumference in a European-derived Brazilian population?
Population
335 individuals from a European-derived Brazilian population
Comparison
Genetic variants in ADRB2, ADRB3, and GNB3… vs Individuals without these specific polymorphisms
Design
Cross-sectional
Authors
Loading...
Should not alter obesity risk assessment; hypothesis-generating for male-specific ADRB2 effects needing replication.
Observational (n=335)
Do variants in ADRB2, ADRB3, and GNB3 genes affect body mass index and waist circumference in a European-derived Brazilian population?
The ADRB2 Arg16Gly polymorphism is associated with increased body mass index and waist circumference specifically in males of European descent in Brazil, highlighting sex-specific genetic effects in obesity.
Mattevi et al. (2006) conducted an observational in Obesity-related traits (n=335). ADRB2, ADRB3, and GNB3 gene polymorphisms was evaluated on Body mass index and waist circumference. The ADRB2 Arg16Gly polymorphism was associated with higher body mass index and waist circumference exclusively in males, with no significant associations found for ADRB3 and GNB3 variants.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: