Key result
Acute intravenous infusion of ketorolac did not impair cardiovagal or sympathetic baroreflex sensitivity or augment pressor reactivity compared to saline in healthy young adults.
Why the study?
Does acute intravenous ketorolac impair baroreflex sensitivity or augment pressor reactivity in healthy young adults?
Population
24 healthy young adults (n=12 in ketorolac group, age 24 +/- 1 yr; n=12 in saline group, age 25 +/- 1 yr)
Comparison
Ketorolac 45 mg intravenous infusion vs Saline intravenous infusion
Design
Other
Follow-up
60 minutes
Authors
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No baroreflex impairment with acute ketorolac in healthy young adults; leaves open effects in older or diseased populations.
Does acute intravenous ketorolac impair baroreflex sensitivity or augment pressor reactivity in healthy young adults?
Acute pharmacological antagonism of the COX enzyme with ketorolac does not impair cardiovagal or sympathetic baroreflex sensitivity or augment pressor reactivity in healthy young adults.
Monahan et al. (2004) studied Healthy young adults (n=24). Ketorolac vs. Saline was evaluated on Cardiovagal and sympathetic baroreflex sensitivity (BRS). Acute intravenous infusion of ketorolac did not impair cardiovagal or sympathetic baroreflex sensitivity or augment pressor reactivity compared to saline in healthy young adults.
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