September 6, 2006AJP Renal Physiology

Low plasma renin and reduced renin secretory responses to acute stimuli in conscious COX-2-deficient mice

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Why the study?

Does COX-2 deficiency reduce plasma renin concentration responses to acute stimuli in conscious mice?

Population

Conscious wild-type and cyclooxygenase-2-/- mice on three different genetic backgrounds

Comparison

Acute intraperitoneal administration of… vs Wild-type mice on the same genetic backgrounds

Design

Preclinical

Authors

SKSoo Mi KimChonbuk National University Hospital LCLimeng ChenDian Diagnostics (China)DMDiane MizelNational Institutes of Health

Discussion

Member takes

Implication

Blunted renin in COX-2-deficient mice; hypothesis-generating for COX-2 inhibitor effects on renin in humans.

Structured PICO

Does COX-2 deficiency reduce plasma renin concentration responses to acute stimuli in conscious mice?

Population

Conscious wild-type (WT) and cyclooxygenase (COX)-2-/- mice on three different genetic backgrounds (mixed, C57BL/6, 129J)

Intervention

Acute intraperitoneal administration of furosemide (40 mg/kg), hydralazine (2 mg/kg), isoproterenol (10 mg/kg), candesartan (50 microg), or quinaprilate (50 microg); and low-NaCl diet with enalapril for 1 week

Comparator

Wild-type (WT) mice on the same genetic backgrounds

Outcome

Plasma renin concentration (PRC) measured in plasma obtained by tail vein puncturesurrogate

Chronic absence of COX-2 reduces renin expression, release, and plasma renin concentration, and blunts the renin response to acute stimulation regardless of the stimulus.

Cite This Study

Kim et al. (2006) studied this question.

synapsesocial.com/papers/6a81f4ddac3bbfe76d61013f https://doi.org/10.1152/ajprenal.00317.2006

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Low plasma renin and reduced renin secretory responses to acute stimuli in conscious COX-2-deficient mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Low plasma renin and reduced renin secretory responses to acute stimuli in conscious COX-2-deficient mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider