Key result
A microstructurally motivated mathematical model of active strain type successfully reproduced the main indicators of normal cardiac function along the whole PV-loop.
Population
Mathematical model of the left ventricle adopting a 'prolate ellipsoid' geometry
Authors
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Supports sarcomere-based active strain models for normal PV-loop simulation; extends computational tools but leaves open clinical validation.
A microstructurally motivated mathematical model of active strain type can reproduce normal cardiac function indicators along the PV-loop using only the shortening ratio of sarcomere units.
Pezzuto et al. (2014) studied Normal cardiac function. Mathematical modeling of left ventricular contraction was evaluated on Simulation of normal cardiac function along the PV-loop and muscle torsion. A microstructurally motivated mathematical model of active strain type successfully reproduced the main indicators of normal cardiac function along the whole PV-loop.
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