Key result
Enalapril increased gap junctional conductance by 219 +/- 20.3% in cardiomyopathic cell pairs with low conductance, indicating the decline is partly due to renin-angiotensin system activation.
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Hypothesis-generating for RAS-mediated gap junction restoration in cardiomyopathy; leaves open clinical translation in patients.
Walmor C. De Mello (1996) studied Cardiomyopathy. Renin-angiotensin system modulators (Angiotensin II, Enalapril, Losartan) vs. Normal hamsters / untreated cells was evaluated on Gap junctional conductance (gj). Enalapril increased gap junctional conductance by 219 +/- 20.3% in cardiomyopathic cell pairs with low conductance, indicating the decline is partly due to renin-angiotensin system activation.
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