Key result
Aggressive hypotensive-drug therapy resulted in 55% (11/20) 1-year survival in patients with malignant hypertension and renal insufficiency, without necessarily deteriorating renal function.
Why the study?
Does aggressive hypotensive-drug therapy improve survival in patients with malignant hypertension complicated by renal insufficiency?
Population
20 patients with malignant hypertension complicated by renal insufficiency
Design
Case_series
Follow-up
up to >8 years
Authors
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May support aggressive BP control in malignant hypertension with renal insufficiency; hypothesis-generating case series requiring randomized confirmation.
Observational (n=20)
Does aggressive hypotensive-drug therapy improve survival in patients with malignant hypertension complicated by renal insufficiency?
Aggressive blood pressure reduction in malignant hypertension with renal insufficiency may prolong survival without necessarily causing deterioration of renal function.
Woods et al. (1974) conducted an observational in Malignant hypertension complicated by renal insufficiency (n=20). Aggressive hypotensive-drug therapy (thiazide diuretic, hydralazine, and guanethedine) was evaluated on 1-year survival. Aggressive hypotensive-drug therapy resulted in 55% (11/20) 1-year survival in patients with malignant hypertension and renal insufficiency, without necessarily deteriorating renal function.
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