Why the study?
Does treatment with antihypertensive agents improve five-year survival in patients with malignant hypertension?
Does treatment with antihypertensive agents improve five-year survival in patients with malignant hypertension?
Early treatment of malignant hypertension with antihypertensive agents significantly improves 5-year survival, demonstrating benefit across racial groups and in patients with advanced atherosclerosis.
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May support early antihypertensives in malignant hypertension; hypothesis-generating, needs RCTs before changing practice.
In this article, Freis and Mohler, a medical student at Georgetown University, reported the findings of their five-year study on the survival rate among patients with malignant hypertension. They concluded that treatment with antihypertensive agents prior to renal failure greatly enhanced a patient's chances for survival, and even proved to provide a greater chance for patients who also had advanced atherosclerosis as a result of prolonged high blood pressure. Freis and Mohler also noted that African American patients who received treatment lived almost as long as white patients in the study.
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Mohler et al. (1960) studied this question.
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