Key result
Hydrogen peroxide and xanthine/xanthine oxidase stimulate Na-K pump activity in cultured bovine pulmonary arterial endothelial cells, mediated by increased intracellular sodium and pump turnover.
Population
Cultured bovine pulmonary arterial endothelial cells (PAECs)
Design
Preclinical
Follow-up
30-min incubations
Authors
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Animal data suggest compensatory endothelial response; leaves open translation to human pulmonary vascular disease or therapy.
H2O2 increases Na-K pump activity in pulmonary arterial endothelial cells, suggesting this may be an early compensatory response and marker of oxidant-induced endothelial perturbation.
Meharg et al. (1993) studied Oxidant injury to pulmonary vascular endothelium. H2O2 or xanthine plus xanthine oxidase was evaluated on Na-K pump activity (ouabain-inhibitable K+ uptake). Hydrogen peroxide and xanthine/xanthine oxidase stimulate Na-K pump activity in cultured bovine pulmonary arterial endothelial cells, mediated by increased intracellular sodium and pump turnover.
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