November 1, 1989Clinical Science
Sympathetic Vasoconstriction as a Mechanism of Action of Ouabain in Forearm Arterioles of Hypertensive Patients
Key result
Intra-arterial infusion of ouabain decreased forearm blood flow, an effect abolished by local sympatholysis, suggesting it acts by enhancing sympathetic neurotransmitter release.
Why the study?
Does intra-arterial ouabain decrease forearm blood flow via sympathetic mechanisms in patients with uncomplicated hypertension?
Population
Patients with uncomplicated hypertension
Comparison
Intra-arterial infusion of ouabain vs Local pretreatment with phentolamine, bretylium…
Design
Other
Authors
Discussion
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Member takes
Implication
Supports sympathetic vasoconstriction by ouabain in hypertensive patients; leaves open systemic relevance and requires confirmation.
Structured PICO
Does intra-arterial ouabain decrease forearm blood flow via sympathetic mechanisms in patients with uncomplicated hypertension?
P
Population
Patients with uncomplicated hypertension undergoing forearm blood flow studies.
I
Intervention
Intra-arterial infusion of ouabain
C
Comparator
Local pretreatment with phentolamine, bretylium tosylate, or histamine
O
Outcome
Forearm blood flowsurrogate
Ouabain causes sympathetically mediated vasoconstriction in human forearm arterioles, likely by enhancing presynaptic neurotransmitter release.
Cite This Study
Pedrinelli et al. (1989) studied uncomplicated hypertension. Intra-arterial infusion of ouabain was evaluated on forearm blood flow. Intra-arterial infusion of ouabain decreased forearm blood flow, an effect abolished by local sympatholysis, suggesting it acts by enhancing sympathetic neurotransmitter release.