Key result
Halothane and sevoflurane inhibited intracellular Ca2+ transients to a greater extent in neonatal rat cardiac myocytes (80% and 50% inhibition, respectively) compared with adults.
Volatile anesthetics cause greater myocardial depression in neonates primarily through the inhibition of Na+-Ca2+ exchange and Ca2+ influx channels rather than sarcoplasmic reticulum Ca2+ release.
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Suggests greater neonatal myocardial sensitivity to volatiles; leaves open human translation and clinical relevance.
Prakash et al. (2002) studied this question. Volatile anesthetics (halothane and sevoflurane) vs. Adult rat cardiac myocytes was evaluated on Intracellular Ca2+ concentration transients during electrical stimulation. Halothane and sevoflurane inhibited intracellular Ca2+ transients to a greater extent in neonatal rat cardiac myocytes (80% and 50% inhibition, respectively) compared with adults.
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