Key result
Ramipril and enalapril showed comparable antihypertensive efficacy, with 55% of the ramipril group and 59% of the enalapril group responding to monotherapy by 12 weeks.
Why the study?
Does ramipril reduce blood pressure comparably to enalapril in patients with mild to moderate essential hypertension?
Population
202 patients (174 evaluable for efficacy) with mild to moderate essential hypertension
Comparison
Ramipril 5 mg single morning dose for 12 weeks vs Enalapril 10 mg single morning dose for 12 weeks
Design
RCT, randomized, parallel group, double-blind
Follow-up
12 weeks
Authors
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Supports selecting either agent by tolerability or cost; extends head-to-head RCT data on ACE inhibitor equivalence.
RCT (n=202)
Double-blind
randomized
Yes
Does ramipril reduce blood pressure comparably to enalapril in patients with mild to moderate essential hypertension?
Absolute Event Rate: 55% vs 59%
Ramipril (5-10 mg) and enalapril (10-20 mg) have comparable antihypertensive efficacy in mild to moderate hypertension, with ramipril showing slightly fewer adverse events.
Zabludowski et al. (1988) conducted an RCT in mild to moderate essential hypertension (n=202). Ramipril vs. Enalapril 10 to 20 mg daily was evaluated on Responder (achievement of a supine diastolic blood pressure of 90 mmHg or less). Ramipril and enalapril showed comparable antihypertensive efficacy, with 55% of the ramipril group and 59% of the enalapril group responding to monotherapy by 12 weeks.
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