Key result
Mast cells are an unlikely source of renin in the heart under normal and pathophysiological conditions, as cardiac angiotensin I-generating activity was not influenced by mast cell number or degranulation.
Mast cells are unlikely to be a significant source of cardiac renin under normal or pathophysiological conditions.
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Should not change clinical renin-angiotensin inhibition strategies; leaves open identification of dominant cardiac renin sources in humans.
Krop et al. (2009) studied Myocardial infarction / Mastocytosis. Mast cell renin release evaluation was evaluated on Angiotensin I-generating activity and renin release. Mast cells are an unlikely source of renin in the heart under normal and pathophysiological conditions, as cardiac angiotensin I-generating activity was not influenced by mast cell number or degranulation.
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