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February 1, 1982AJP Heart and Circulatory Physiology

Sympathetic transients caused by abrupt alterations of carotid baroreceptor activity in humans

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Key result

Application of 30-mmHg neck suction or pressure showed that increased carotid transmural pressure totally inhibited sympathetic activity after a latency of about 2 seconds.

Why the study?

Does modification of carotid baroreceptor activity alter sympathetic and parasympathetic outflow in healthy adults?

Population

10 healthy adults

Comparison

Modification of afferent carotid baroreceptor… vs Opposite pressure changes

Design

Other

Authors

BWB. G. WallinUniversity of GothenburgDED. L. EckbergUniversity of Richmond

Discussion

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Implication

Transient sympathetic inhibition in healthy adults warrants no clinical change; leaves open distinct central vagal versus sympathetic baroreflex pathways.

Key Points

  • This research investigates how carotid baroreceptors affect sympathetic and parasympathetic nervous system outputs in humans.
  • Examined 10 healthy adults
  • Modified carotid baroreceptor activity with neck suction or pressure
  • Measured sympathetic activity in peroneal nerve with microelectrodes
  • Increased carotid pressure totally inhibited sympathetic activity
  • Decreased carotid pressure augmented sympathetic activity
  • Cardiac intervals changed in response to arterial pressure changes, demonstrating a distinct adaptation pattern

Structured PICO

Does modification of carotid baroreceptor activity alter sympathetic and parasympathetic outflow in healthy adults?

P
Population
10 healthy adults undergoing physiological assessment of carotid baroreceptor activity.
I
Intervention
Modification of afferent carotid baroreceptor activity with 30-mmHg neck suction or pressure applied during held expiration
C
Comparator
Opposite pressure changes (increased vs decreased carotid transmural pressure)
O
Outcome
Efferent sympathetic activity (measured with microelectrodes in peroneal nerve) and parasympathetic outflow to the heart (cardiac intervals)surrogate

Muscle sympathetic responses to changing levels of afferent baroreceptor traffic are profound but transitory, suggesting common baroreceptor input is processed differently in central vagal and sympathetic networks.

Cite This Study

Wallin et al. (1982) studied Healthy (n=10). Neck suction or pressure was evaluated on Sympathetic outflow to the muscle vascular bed and parasympathetic outflow to the heart. Application of 30-mmHg neck suction or pressure showed that increased carotid transmural pressure totally inhibited sympathetic activity after a latency of about 2 seconds.

synapsesocial.com/papers/6a2308d03bf314e836cb27e5https://doi.org/10.1152/ajpheart.1982.242.2.h185
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Carotid baroreceptor-muscle sympathetic relation in humans1987 · 77 citations
  2. 2Differential baroreflex modulation of human vagal and sympathetic activity1991 · 40 citations
  3. 3Effects of dynamic and static neck suction on muscle nerve sympathetic activity, heart rate and blood pressure in man.1981 · 77 citations
  4. 4Slowing of carotid-cardiac baroreflex with standing and with isometric and dynamic muscle activity1996 · 16 citations
  5. 5The effect of baroreceptors on the latency of evoked responses in sympathetic nerves during the cardiac cycle1973 · 8 citations