Key result
Carotid baroreceptor stimulation via a neck chamber device induced a significant, transient reduction in central venous pressure that weakly correlated with RR interval lengthening (r=0.32, P<0.05).
Why the study?
It was unknown whether carotid baroreceptor stimulation via the neck chamber device affects central venous pressure, potentially involving other reflexogenic areas in the responses.
Does carotid baroreflex stimulation via a neck chamber device affect central venous pressure in young subjects?
Does carotid baroreflex stimulation via a neck chamber device affect central venous pressure in young subjects?
Carotid baroreceptor stimulation via a neck chamber device transiently reduces central venous pressure, suggesting that this technique may concomitantly engage cardiopulmonary receptors.
Answers are grounded in this paper and cite their sources.
May suggest baroreflex effects on venous tone; hypothesis-generating and requires validation before any clinical consideration.
We examined in 11 young subjects (age 29.7±3.6 years, mean±SEM) whether carotid baroreceptor stimulation via the neck chamber device may affect central venous pressure (CVP), thus potentially involving other reflexogenic areas in the examined responses. Application of progressively greater neck chamber subatmospheric pressures caused a progressive lengthening in RR interval, which reached a peak at the maximal value of negative neck chamber pressure applied. This was accompanied by significant and progressively greater reduction in CVP values when the data were calculated considering the early changes occurring within the first 2 seconds of the stimulus. There was a weak correlation between the early changes in CVP and the RR interval responses when all stimuli were pooled together (r = 0.32, P < .05). The results of the present study suggest that the neck chamber technique employed to assess carotid baroreceptor-heart rate sensitivity can transiently affect via the CVP reduction cardiopulmonary receptors activity, which may participate at the integrated reflex responses.
No takes yet. Share an insight, caveat, or question.
Quarti‐Trevano et al. (2021) studied Normal autonomic function (history of single syncope episode) (n=11). Carotid baroreceptor stimulation via neck chamber device vs. Pre-stimulus baseline was evaluated on Early changes in central venous pressure (CVP) within the first 2 seconds of stimulus (r = 0.32, p=<.05). Carotid baroreceptor stimulation via a neck chamber device induced a significant, transient reduction in central venous pressure that weakly correlated with RR interval lengthening (r=0.32, P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: