What is the clinical evidence from this study?

Study design: Other. Population: Normal autonomic function (history of single syncope episode) (n=11). Intervention: Carotid baroreceptor stimulation via neck chamber device vs. Pre-stimulus baseline. Primary outcome: Early changes in central venous pressure (CVP) within the first 2 seconds of stimulus (r = 0.32, p=<.05).

November 16, 2021Open Access

Transient effects of carotid baroreflex stimulation via the neck chamber device on central venous pressure

Q: What are the key findings of this study?

Carotid baroreceptor stimulation via a neck chamber device induced a significant, transient reduction in central venous pressure that weakly correlated with RR interval lengthening (r=0.32, P<0.05).

FQFosca Quarti‐TrevanoAzienda Ospedaliera San Gerardo GSGino SeravalleGeneral Cardiology DSDomenico SpazianiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Key Result

Carotid baroreceptor stimulation via a neck chamber device induced a significant, transient reduction in central venous pressure that weakly correlated with RR interval lengthening (r=0.32, P<0.05).

Structured PICO

Does carotid baroreflex stimulation via a neck chamber device affect central venous pressure in young subjects?

Population

11 young adults (mean age 29.7 years, 27.3% female) with a single prior syncope episode but normal autonomic function underwent physiological testing.

Intervention

Carotid baroreceptor stimulation via a neck chamber device applying subatmospheric pressures ranging from -7 to -40 mmHg in four separate 10-second steps.

Comparator

Baseline values recorded in the 3 minutes before the stimuli.

Outcome

Changes in central venous pressure (CVP) and RR interval during the stimulus.surrogate

Carotid baroreceptor stimulation via a neck chamber device transiently reduces central venous pressure, suggesting that this technique may concomitantly engage cardiopulmonary receptors.

Main Result

Effect estimate: r = 0.32

p-value: p=<.05

Limitations

Small population sample size preventing definite conclusions.
Findings in patients with a first episode of syncope cannot be safely extrapolated to hypertensive patients without a history of syncope.

Abstract

We examined in 11 young subjects (age 29.7±3.6 years, mean±SEM) whether carotid baroreceptor stimulation via the neck chamber device may affect central venous pressure (CVP), thus potentially involving other reflexogenic areas in the examined responses. Application of progressively greater neck chamber subatmospheric pressures caused a progressive lengthening in RR interval, which reached a peak at the maximal value of negative neck chamber pressure applied. This was accompanied by significant and progressively greater reduction in CVP values when the data were calculated considering the early changes occurring within the first 2 seconds of the stimulus. There was a weak correlation between the early changes in CVP and the RR interval responses when all stimuli were pooled together (r = 0.32, P < .05). The results of the present study suggest that the neck chamber technique employed to assess carotid baroreceptor-heart rate sensitivity can transiently affect via the CVP reduction cardiopulmonary receptors activity, which may participate at the integrated reflex responses.

Ask AI

Helpful

Bookmark

View Full Paper