Key result
Reduced sarcoplasmic reticulum calcium uptake and release promote arrhythmogenic spatially and electromechanically discordant alternans in a computational tissue model.
Population
Computational model of cardiac tissue incorporating a detailed single cell coupled map model of calcium…
Comparison
Variation of sarcoplasmic reticulum calcium… vs Different rates of SR calcium uptake and release
Design
Preclinical
Authors
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Hypothesis-generating for calcium-driven arrhythmias; leaves open validation in experimental models before clinical consideration.
Computational modeling reveals that reduced sarcoplasmic reticulum calcium uptake and release promote arrhythmogenic spatially and electromechanically discordant alternans.
Seth H. Weinberg (2016) studied Cardiac alternans and conduction block. Sarcoplasmic reticulum calcium uptake and release properties was evaluated on Alternans and conduction block. Reduced sarcoplasmic reticulum calcium uptake and release promote arrhythmogenic spatially and electromechanically discordant alternans in a computational tissue model.
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