Key result
Elderly patients with postural hypotension exhibited a smaller stroke volume decrease (23% vs 35%; P<0.001) and no increase in peripheral resistance during head-up tilt compared to healthy controls.
Why the study?
Do haemodynamic and neurohumoral responses to head-up tilt differ between elderly patients with postural hypotension and healthy elderly subjects?
Case-Control (n=40)
Do haemodynamic and neurohumoral responses to head-up tilt differ between elderly patients with postural hypotension and healthy elderly subjects?
Absolute Event Rate: 23% vs 35%
p-value: p=<0.001
Elderly patients with postural hypotension exhibit impaired peripheral resistance responses to tilting despite normal neurohumoral responses, suggesting end-organ failure.
No takes yet. Share an insight, caveat, or question.
Impaired vasoconstriction may underlie postural hypotension in elderly patients; hypothesis-generating and should not yet change practice.
Lye et al. (1990) conducted a case-control in Postural hypotension (n=40). Postural hypotension vs. Healthy elderly subjects was evaluated on Stroke volume decrease on head-up tilt (p=<0.001). Elderly patients with postural hypotension exhibited a smaller stroke volume decrease (23% vs 35%; P<0.001) and no increase in peripheral resistance during head-up tilt compared to healthy controls.
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