Key result
Switching from amlodipine to nisoldipine resulted in similar 24-hour ambulatory blood pressure profiles, with a 2 mm Hg difference in 24-hour diastolic pressure (77 vs 75 mm Hg; p<0.05).
Why the study?
Does switching from amlodipine to nisoldipine maintain 24-hour blood pressure control in patients with essential hypertension?
Population
25 patients with stage I or II essential hypertension stabilized with amlodipine for at least 3 months
Comparison
Nisoldipine 10 mg/day or 20 mg/day for a mean of… vs Amlodipine 5 or 10 mg/day
Design
Cohort, Open-label
Follow-up
mean 10.6 weeks
Authors
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May support switch feasibility in select patients; leaves open broader equivalence pending randomized data.
Does switching from amlodipine to nisoldipine maintain 24-hour blood pressure control in patients with essential hypertension?
Absolute Event Rate: 77% vs 75%
p-value: p=<0.05
Switching from amlodipine to nisoldipine maintains similar 24-hour ambulatory blood pressure profiles with comparable rates of lower extremity edema.
Lenz et al. (2001) studied Stage I or II essential hypertension (n=25). Nisoldipine vs. Amlodipine 5 or 10 mg/day was evaluated on 24-hour diastolic pressure (p=<0.05). Switching from amlodipine to nisoldipine resulted in similar 24-hour ambulatory blood pressure profiles, with a 2 mm Hg difference in 24-hour diastolic pressure (77 vs 75 mm Hg; p<0.05).
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