Key result
IL-6 deficiency markedly reduced the prevalence and severity of autoimmune myocarditis in mice, associated with impaired upregulation of complement C3 and poor expansion of autoimmune CD4+ T cells.
Why the study?
Does IL-6 deficiency prevent the development of autoimmune myocarditis in a mouse model?
Population
IL-6-deficient mice and IL-6+/+ mice immunized with a peptide derived from cardiac alpha-myosin, and…
Comparison
IL-6 deficiency (genetic knockout) vs IL-6+/+ (wild-type) mice
Design
Preclinical
Authors
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Positions IL-6 as candidate target in autoimmune myocarditis; animal data leave open human translation.
Does IL-6 deficiency prevent the development of autoimmune myocarditis in a mouse model?
IL-6 is required for the expansion of autoimmune CD4+ T cells and the pathogenesis of autoimmune myocarditis, potentially via complement C3 upregulation.
Eriksson et al. (2003) studied Autoimmune myocarditis. IL-6 deficiency vs. IL-6+/+ (wild-type) mice was evaluated on Prevalence and severity of myocarditis. IL-6 deficiency markedly reduced the prevalence and severity of autoimmune myocarditis in mice, associated with impaired upregulation of complement C3 and poor expansion of autoimmune CD4+ T cells.
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