Key result
Left atrial global longitudinal strain (AUC 0.82) and amplified p-wave duration (AUC 0.90) effectively identified patients with atrial fibrillation at risk for left atrial appendage thrombus.
Why the study?
Atrial cardiomyopathy is linked to left atrial thrombogenesis, but thresholds of echocardiographic LA strain and amplified p-wave duration to identify AF patients at risk were undefined.
Can LA-GLS and APWD identify patients with atrial fibrillation at risk for left atrial appendage thrombogenesis?
Comparison
Patients with LAA-thrombus vs control group
Design
Cross-sectional diagnostic study
Authors
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LA-GLS and APWD may aid LAA thrombus risk stratification in AF; hypothesis-generating and requires prospective validation before clinical use.
Cross-Sectional (n=128)
Can LA-GLS and APWD identify patients with atrial fibrillation at risk for left atrial appendage thrombogenesis?
Effect estimate: AUC 0.82 for LA-GLS; AUC 0.90 for APWD
p-value: p=<0.001
LA-GLS and APWD are non-invasive markers that can help identify patients with atrial fibrillation at high risk for left atrial appendage thrombus.
Huang et al. (2022) conducted a cross-sectional in Atrial fibrillation (n=128). Left atrial global longitudinal strain (LA-GLS) and amplified p-wave duration (APWD) vs. Control group (without LAA thrombus) was evaluated on Left atrial appendage (LAA) thrombus (AUC 0.82 for LA-GLS; AUC 0.90 for APWD, p=<0.001). Left atrial global longitudinal strain (AUC 0.82) and amplified p-wave duration (AUC 0.90) effectively identified patients with atrial fibrillation at risk for left atrial appendage thrombus.
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