Key result
Adv/RSV-THM significantly reduced the intima-to-media ratio to 0.47% compared to 0.77% in viral controls 28 days after mechanical overdilation injury in rabbit femoral arteries.
Why the study?
Does local overexpression of thrombomodulin via an adenoviral vector reduce neointima formation after mechanical overdilation injury in a rabbit model?
Does local overexpression of thrombomodulin via an adenoviral vector reduce neointima formation after mechanical overdilation injury in a rabbit model?
Absolute Event Rate: 0.47% vs 0.77%
Local overexpression of thrombomodulin via an adenoviral vector significantly decreases neointima formation, local inflammation, and early thrombus formation after mechanical overdilation injury in a rabbit model.
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Preclinical support for thrombomodulin gene therapy in restenosis models; leaves open human translation.
Waugh et al. (2000) studied Neointima formation after mechanical overdilation injury (n=12). Adv/RSV-THM (adenoviral construct expressing thrombomodulin) vs. Buffer or viral control was evaluated on Intima-to-media (I/M) ratio at 28 days. Adv/RSV-THM significantly reduced the intima-to-media ratio to 0.47% compared to 0.77% in viral controls 28 days after mechanical overdilation injury in rabbit femoral arteries.
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