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June 1, 1957British Journal of Pharmacology and ChemotherapyOpen Access

A Comparative Study of Kinin, Kallidin, and Bradykinin

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Authors

DHDouglas HoldstockAlbemarle (United States)AMA. P. MathiasHospital do Servidor Público EstadualMSM SchachterChildren's Hospital of Philadelphia

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Implication

Comparative study evaluates kinin compounds on capillary permeability in guinea pigs and rabbits, suggesting implications for physiological roles.

Key Points

  • The study aims to compare the effects of kinin, kallidin, and bradykinin on smooth muscle stimulation and capillary permeability.
  • Examined the potency of partially purified kinin against histamine and acetylcholine.
  • Evaluated the effects of kallikrein and trypsin on the release of kallidin or bradykinin.
  • Conducted chemical and pharmacological tests to differentiate between kallidin and bradykinin.
  • Kinin was 10 to 100 times more effective than histamine in enhancing capillary permeability.
  • Kinin was 10 times more effective than acetylcholine in evoking pain on a cutaneous blister base.
  • Chemical tests indicated that kallidin and bradykinin are closely similar with no significant differentiation.

Cite This Study

Holdstock et al. (1957) studied this question.

synapsesocial.com/papers/6a231e14386be3bc61656c5ahttps://doi.org/10.1111/j.1476-5381.1957.tb00113.x
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