Forskolin induces desensitization of the nicotinic acetylcholine receptor in skeletal muscle, suggesting a role for cAMP-dependent phosphorylation in this process.
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Forskolin effects on AChR suggest caution with cAMP-elevating agents in neuromuscular contexts; hypothesis-generating for phosphorylation mechanisms in receptor desensitization.
Albuquerque et al. (1986) studied this question.
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