Why the study?
How do isolated coronary arteries from various species respond to epinephrine, acetylcholine, and histamine?
How do isolated coronary arteries from various species respond to epinephrine, acetylcholine, and histamine?
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This preclinical study demonstrates that acetylcholine and histamine consistently cause vasoconstriction in isolated coronary arteries across multiple species, while the response to epinephrine is variable.
Summary1. The method of employing angioplethysmokymography to evaluate the responses of coronary arteries to several drugs is described.2. Epinephrine did not produce a uniform response in the coronary arteries examined. The relation of this inconsistency to the state of vasodilation of the specimen artery is discussed.3. Acetylcholine was found to produce consistent coronary vasoconstriction in man, pig and sheep.4. Histamine uniformly produces vasconstriction of the coronary arteries of man, pig, ox and sheep.
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David J. Smith (1950) studied this question.
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