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Do histamine and acetylcholine cause vasoconstriction in isolated human and swine coronary arteries?
Do histamine and acetylcholine cause vasoconstriction in isolated human and swine coronary arteries?
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This in vitro study demonstrates that histamine and acetylcholine induce coronary vasoconstriction in human and swine arteries, which can be blocked by specific antagonists.
A new in vitro technic for the study of isolated surviving arteries and veins is described. Observations of the reactivity of 21 human and 68 swine coronary arteries to histamine, acetylcholine, l -epinephrine and l -norepinephrine are reported. Histamine and acetylcholine uniformly caused vasoconstriction of the coronary arteries of man and swine. Three potential mechanisms of coronary artery vasoconstriction in these species are suggested. The blocking action of antihistaminic drugs on vasoconstriction due to histamine, and of atropine on vasoconstriction due to acetylcholine is demonstrated. It is suggested that combined therapy with these drugs may be useful in treatment of diseases of the coronary arteries.
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Smith et al. (1951) studied this question.
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