Effects of Chronic Calcium Channel Blockade on Sympathetic Nerve Activity in Hypertension
Key result
Slow release forms of verapamil, nifedipine, and amlodipine exerted comparable antihypertensive effects and did not significantly change muscle sympathetic nerve activity (P=NS).
Why the study?
Do amlodipine, nifedipine, or verapamil differ in their effects on muscle sympathetic nerve activity in patients with mild to moderate hypertension?
Population
43 patients (31 men, 12 women) with mild to moderate hypertension
Comparison
Amlodipine, nifedipine, or verapamil for 8 weeks vs Active comparators
Design
RCT, randomly assigned
Follow-up
8 weeks
Authors
Discussion
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Implication
Supports interchangeable slow-release CCB selection in hypertension; confirms neutral MSNA effects across agents.
Study Design
Type
RCT (n=43)
Randomization
randomly assigned
Structured PICO
Do amlodipine, nifedipine, or verapamil differ in their effects on muscle sympathetic nerve activity in patients with mild to moderate hypertension?
P
Population
43 patients with mild to moderate hypertension treated with amlodipine, nifedipine, or verapamil for 8 weeks.
I
Intervention
Amlodipine, nifedipine, or verapamil (slow release forms) for 8 weeks
C
Comparator
Active comparators (amlodipine vs nifedipine vs verapamil)
O
Outcome
Muscle sympathetic nerve activity (MSA) measured by microneurography at 8 weekssurrogate
Main Result
p-value: p=NS
Slow release forms of verapamil, nifedipine, and amlodipine exert comparable antihypertensive effects and do not significantly change muscle sympathetic nerve activity in mild to moderate hypertension.
Cite This Study
Binggeli et al. (2002) conducted an RCT in mild to moderate hypertension (n=43). Amlodipine, nifedipine, or verapamil vs. Active comparators was evaluated on muscle sympathetic nerve activity (MSA) (p=NS). Slow release forms of verapamil, nifedipine, and amlodipine exerted comparable antihypertensive effects and did not significantly change muscle sympathetic nerve activity (P=NS).