Why the study?
Do felodipine and verapamil have differential effects on autonomic and baroreflex function in patients with essential hypertension?
Population
15 subjects with essential hypertension
Comparison
Felodipine and Verapamil, administered acutely… vs Placebo
Design
Other
Follow-up
4 weeks
Authors
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Chronic verapamil may suppress sympathetic activity unlike felodipine in hypertension; leaves open outcome differences in larger trials.
Do felodipine and verapamil have differential effects on autonomic and baroreflex function in patients with essential hypertension?
Verapamil and felodipine have divergent, time-dependent effects on sympathetic nervous system activity, which may explain the differences in their autonomic and hemodynamic side effect profiles.
Kailasam et al. (1995) studied this question.
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