Key result
Heart failure (34.0% vs 14.3%, p=0.0012) and orthostatic hypotension (10.0% vs 2.0%, p=0.036) were significantly more common in patients with white matter low attenuation than in those without.
Why the study?
Are vascular factors associated with white matter low attenuation of the brain on computer tomography?
Population
204 patients with computer tomography findings and sufficient clinical data from hospital records
Design
Cross-sectional
Authors
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Heart failure and orthostatic hypotension were associated with WMLA; hypothesis-generating for hypoperfusion mechanism, needs prospective confirmation before clinical relevance.
Observational (n=204)
Are vascular factors associated with white matter low attenuation of the brain on computer tomography?
Absolute Event Rate: 34% vs 14.3%
p-value: p=0.0012
Vascular factors with hemodynamic significance, such as heart failure and low systolic blood pressure, are associated with white matter low attenuation, suggesting cerebral hypoperfusion contributes to its genesis.
Räihä et al. (1993) conducted an observational in White matter low attenuation of the brain (WMLA) (n=204). White matter low attenuation (WMLA) vs. No WMLA was evaluated on Presence of heart failure (p=0.0012). Heart failure (34.0% vs 14.3%, p=0.0012) and orthostatic hypotension (10.0% vs 2.0%, p=0.036) were significantly more common in patients with white matter low attenuation than in those without.
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