Key result
A three-step hyperinsulinemic glucose clamp increased leg blood flow similarly in men with NIDDM and healthy controls (P>0.05), indicating normal insulin-mediated vasodilation in NIDDM.
Why the study?
Does insulin stimulate leg blood flow normally in patients with NIDDM compared to healthy controls?
Population
15 men, including 8 healthy controls and 7 with non-insulin-dependent diabetes mellitus (NIDDM)
Comparison
Three-step hyperinsulinemic glucose clamp vs Healthy control group
Design
Other
Authors
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Supports preserved insulin vasodilation in NIDDM without practice change; hypothesis-generating for metabolic-vascular coupling in larger cohorts.
Case-Control (n=15)
Does insulin stimulate leg blood flow normally in patients with NIDDM compared to healthy controls?
p-value: p=>0.05
At ambient glucose levels, the effect of insulin in stimulating leg blood flow is normal in patients with NIDDM, and insulin-mediated vasodilation is closely linked to muscle metabolic rate.
Dela et al. (1995) conducted a case-control in Non-insulin-dependent diabetes mellitus (NIDDM) (n=15). Hyperinsulinemic glucose clamp vs. Healthy controls was evaluated on Leg blood flow (LBF) (p=>0.05). A three-step hyperinsulinemic glucose clamp increased leg blood flow similarly in men with NIDDM and healthy controls (P>0.05), indicating normal insulin-mediated vasodilation in NIDDM.
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