Key result
Early-onset inflammatory bowel disease in children was associated with impaired diastolic function, including a lower mitral E/A ratio (1.4 vs 1.70, p=0.004) compared to healthy controls.
Why the study?
Childhood-onset inflammatory bowel disease is more aggressive than adult disease, with early-onset cases exhibiting more severe progression, prompting evaluation of cardiac functions and aortic elasticity during remission.
Does childhood-onset inflammatory bowel disease impair cardiac functions and aortic elasticity in pediatric patients?
Cross-Sectional (n=58)
Does childhood-onset inflammatory bowel disease impair cardiac functions and aortic elasticity in pediatric patients?
Absolute Event Rate: 1.4% vs 1.7%
p-value: p=0.004
Childhood-onset inflammatory bowel disease, particularly early-onset, is associated with subclinical impairment of left ventricular diastolic function even during disease remission.
Subclinical diastolic impairment in early-onset pediatric IBD may warrant monitoring; leaves open prognostic implications and need for longitudinal studies.
AIM: Childhood onset inflammatory bowel disease is more aggressive and has rapidly progressive clinical course than adult inflammatory bowel disease. Early-onset inflammatory bowel disease has more severe clinical progression as a subspecialised group of monogenic inflammatory bowel disease. We studied cardiac functions and aortic elasticity in children with early- and late-onset inflammatory bowel disease in remission period. METHODS: Thirty-three paediatric patients were divided into subgroups according to age of disease onset (<10 and >10 years of age). Twenty-five healthy children were admitted as control group. M-Mode echocardiography and pulsed wave Doppler echocardiography were performed. Strain, distensibility, stiffness index of ascending, and abdominal aorta were evaluated. RESULTS: Interventricular septum (mm) and left ventricular end-systolic diameter were higher (6.9 ± 1.2, 26.2 ± 4.6) in early-onset inflammatory bowel disease patients than control patients (6.1 ± 1.27, 22.7 ± 4.12) (p = 0.050, p = 0.050). Mitral E/E' ratio and myocardial performance index were increased in inflammatory bowel disease and early-onset inflammatory bowel disease groups than control group (p = 0.046, p = 0.04; p = 0.023, p = 0.033). Diastolic functions were found to be impaired in inflammatory bowel disease and early-onset inflammatory bowel disease groups according to control group, while there was no difference between late-onset inflammatory bowel disease and control groups in terms of diastolic functions. Mitral E/A ratio was lower in inflammatory bowel disease patients and early-onset inflammatory bowel disease patients (1.46 ± 0.32, 1.4 ± 0.21) than control patients (1.70 ± 0.27) (p = 0.013, p = 0.004). Aortic elasticity did not differ between groups. CONCLUSION: Chronic low-grade inflammation has effects on left ventricular diameters and diastolic function in remission period. Aortic elasticity is not affected in our study groups.
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Erolu et al. (2020) conducted a cross-sectional in Inflammatory bowel disease (n=58). Early-onset inflammatory bowel disease vs. Healthy children was evaluated on Mitral E/A ratio (p=0.004). Early-onset inflammatory bowel disease in children was associated with impaired diastolic function, including a lower mitral E/A ratio (1.4 vs 1.70, p=0.004) compared to healthy controls.
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