Population
Isolated sarcolemma and intact atrial tissue of guinea-pig
Comparison
R 56865 (10^-7 to 10^-6 mol/L) vs Ouabain alone
Design
Preclinical
Follow-up
3 hours
Authors
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Animal data suggest indirect glycoside antagonism via intact tissue; hypothesis-generating and should not change practice.
R 56865 reduces ouabain binding in intact guinea-pig atria but not in purified sarcolemma, suggesting an indirect mechanism for its antagonism of cardiac glycoside intoxication.
Heers et al. (1991) studied this question.
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