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February 6, 1970Science

Myofibrils in the core of the fiber become wavy as shortening continues, suggesting activation is interrupted by shortening.

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Population

Isolated striated muscle fibers

Design

Preclinical

Authors

STStuart R. TaylorRRReinhardt Rüdel

Discussion

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Overview

Shortening may disrupt activation in cardiac fibers; leaves open its role in human length-tension relations.

Key Points

  • This research aims to understand how shortening affects the activation of myofibrils during muscle contractions.
  • Isolated muscle fibers were subjected to membrane depolarization to initiate contraction.
  • The behavior of myofibrils during lightly loaded contractions was observed as the fibers shortened.
  • Myofibrils maintained a straight shape initially but became wavy during continued shortening, indicating disrupted activation.
  • Shortening interferes with the expected length-tension relationship, particularly at shorter muscle lengths.

Structured PICO

P
Population
Isolated striated muscle fibers
I
Intervention
Lightly loaded contraction initiated by membrane depolarization
O
Outcome
Myofibril structural changes (waviness) during shorteningsurrogate

Shortening-induced inactivation of contraction may be a factor determining the length-tension relation at short muscle lengths.

Cite This Study

Taylor et al. (1970) studied this question.

synapsesocial.com/papers/6a23d9c32dc9ee5f679f03f4https://doi.org/10.1126/science.167.3919.882
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