Population
Single intact frog muscle fibres
Comparison
Active pre-shortening during tetanization vs Isometric contraction without pre-shortening
Design
Preclinical
Authors
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Active preshortening effects in frog fibers should not inform clinical models; leaves open validation in mammalian cardiac muscle.
Active pre-shortening significantly reduces subsequent isometric force in single frog muscle fibers, correlated with the work done during shortening.
Granzier et al. (1989) studied this question.
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